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Effects Of Terminalia Chebula On Blood Biochemical Profile And Pancreatic Tissue In Diabetic Rats.

by Daniyal Kazmi | Dr. Imtiaz Rabbani | Prof. Dr. Habib-ur-Rehman.

Material type: book Book; Format: print ; Literary form: drama Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1834,T] (1).

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2.
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Antiangiogenic Activity Of Extracts Of Vinca Rosea (Catharnathus Roseus) Using Cam Assay

by Ijaz Ahmed | Prof. Dr. Habib-ur-Rehman | Dr. Imtiaz Rabbani | Syed.

Material type: book Book; Format: print Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1835,T] (1).

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Antiulcer Activisty Of Malva Parviflora Leaf Extract Narr Sonhal On Ethanol Induced Gastric Ulcer In Rat

by Sumeera Anjum | Dr. Imtiaz Rabbani | Prof. DR. Habib-ur-Rehman.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2122,T] (1).

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4.
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Gastroprotective Effect Of Grewia Optiva (Dhamna) Leaf Extract On Ethano; Induced Gastric Ulcer In Rats

by Saira Aslam | Dr Imtiaz Rabbani | Prof. DR. Habib-ur-Rehman.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2137,T] (1).

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5.
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In Vitro Study Of The Effect Of Menthol On Electrophysiological Indices Of Isolated Rumen Epithelium In Goat

by Najma Khan (2014-VA-506) | Dr. Imtiaz Rabbani | Prof. Dr. Habib ur Rehman | Dr. Hafsa Zaneb.

Material type: book Book; Literary form: not fiction Publisher: 2016Dissertation note: Ammonia is product of protein metabolism and its reabsorption occur by non-selective cation channels across rumen epithelium otherwise it will not be available as non-protein nitrogen source and excreted out causing hazard to environment. At physiological pH, ammonia is present as NH4+ in rumen and its transport leads to electrophysiological changes. It was reported that addition of menthol to the isolated rumen epithelium of cattle cause electrophysiological changes, primarily linked to the ammonium transport suggesting presence of non-selective cation channels. Addition of cation channel modulators such as menthol to diet can enhance absorption of nitrogen in the rumen. Scarce data was available for rumen epithelium of goats which has a large contribution in livestock population and has a great potential for mutton market revealing effect of cation channel modulators on electrophysiology and ammonium transport. Objective of this study was to investigate the effect of menthol on electrophysiological changes and its link to ammonia transport in the isolated rumen epithelium of goats. Hypothesis Menthol may affect the electrophysiology of the isolated rumen epithelium of goats and enhance ammonia transport across rumen epithelium. Methodology Ten goats of uniform age and weight were selected and slaughtered in a local slaughter house. Reticulorumen was removed from the abdominal cavity and cleaned in a standard transport buffer solution. Serosal layer of rumen was removed and mounted in the Ussing chamber. Rumen epithelium was incubated with transport buffer solution and after 20 minutes replaced with ammonia containing buffer solution (10mM and 40mM respectively) 46 and changes in bioelectric parameters were observed. Menthol in concentration of 1mM was added to mucosal side and electrophysiological parameters like Isc and Gt were observed. Moreover, pH of serosal side was checked after menthol treatment at time intervals 20, 60 and 90 minutes respectively to assess ammonia transport. Results Menthol affected the electrophysiology of isolated rumen epithelium of goats by increasing short circuit current due to increase in ammonia concentrations in the rumen. Menthol addition in 40mM NH4Cl containing solution significantly increased current (p value = 0.00). ΔIsc was also significant between the groups containing 10 and 40mM NH4Cl containing solution. Change in potential difference was significant after addition of menthol in both groups (P = 0.00). Conductance increased significantly by increasing concentration of ammonia (p value = 0.03). PH of serosal side decreased, suggesting possible NH4+ uptake, while on mucosal side increase in pH was observed. Statistical analysis Data were analyzed by using completely randomized ANOVA followed by post-hoc test LSD. Level of significance was set at 0.05. Conclusion Menthol treatment affects the electrophysiological indices of isolated rumen epithelium of goat presumably by opening non-selective cation channels and enhances ammonium transport across rumen epithelium increasing recycling of nitrogen. This may leads to efficient protein utilization by the animals. Availability: Items available for loan: UVAS Library [Call number: 2558-T] (1).

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6.
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Effect Of Bisphenol-A On Glucose Uptake And Electrophysiology Of Isolated Ileum Of Rabbit

by Hina Rafiq (2014-VA-921) | Dr. Imtiaz Rabbani | Prof. Dr. Habib ur Rehman | Dr. Rahat Naseer.

Material type: book Book; Literary form: not fiction Publisher: 2017Dissertation note: A major nutritional problem these days is the biological and chemical contamination of food with environmental chemicals. Bisphenol-A (BPA) is one of a chemical which is produce worldwide and cause food contamination. BPA has many genomic and non-genomic effects and target various organs of both human and animals and cause hazardous effects. BPA cause other diseases such as angina, coronary heart disease, heart attack, stroke, asthma, emphysema, chronic bronchitis, arthritis, thyroid hormone disruption, liver damage and disrupted beta cell function. It has adverse effects on the homeostasis of glucose which leads to the metabolic disorders like insulin resistant type 2 diabetes. BPA also affect the barrier function of small intestine. The current study was aimed to investigate the effect of BPA on the barrier function of intestine. Bisphenol-A (BPA) wasdisrupt glucose uptake and perturb the gut barrier function. Our study aimed to find out the effect of Bisphenol-A on the electrophysiology of ileum of small intestine of rabbit.For this purpose twenty healthy rabbits of uniform age and weight were selected and slaughtered at slaughter house of UVAS. Ileum was taken from the intestinal part and rinsed with standard buffer. Serosallayer was removed and tissue was mounted in Ussing Chamber. After incubation period of 15-20mins different groups were treated with different concentrations of BPA anddivided into four groups (A, B, C, and D), each having five rabbits. Group A, was control. In group B, tissue was treated with Bisphenol-A 5 µM. Group C was treated with 15 µM of Bisphenol-A, and group D was treated with 30µM of Bisphenol-A. After treatment the electrophysiological parameters like short circuit current (Isc), conductance (Gt) and potential difference (mV)was observed. BPA affected the electrophysiology of isolated ileum of rabbit by decreasing the short circuit current. The decrease of current between the groups is significant (p value < 0.05). Iscwas significantly decrease between the groups containing 5µМ BPA and control group.Gtwas significantly different from group 5µМ and group 15µМ of BPA.mV was significantly different from control group and group 15µМ of BPA. Statistical analysis was conducted with statistical packages for social sciences (SPSS). The data were analyzed using one way analysis of variance (ANOVA). Post hoc test was carried out using Tukey. P value was considered significant at P<0.05. The result of this study showed that BPA 5µM effects the electrophysiology of intestine as compared to other groups (15 µM and 30 µM). Suggesting a possible role of BPA in affected intestinal barrier function and glucose uptake. Availability: Items available for loan: UVAS Library [Call number: 2838-T] (1).

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